ArtNr |
CSB-AP000521MO-1 |
Hersteller |
Cusabio
|
Menge |
1mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Mouse |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Classification |
Others |
Subdivision |
Others |
Research Areas |
Cancer |
Uniprot NO. |
Q62226 |
Uniprot Entry Name |
SHH_MOUSE |
Gene Names |
Shh, Hhg1 |
Source |
E.Coli |
Expression Region |
26-198aa |
Sequence |
IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AE KTLGASGR YEGKITRNSE RFKELTPNYN PDII FKDEEN TGADRLMTQR CKDKLNALAI SVMNQW PGVK LRVTEGWDED GHHSEESLHY EGRAVDIT TS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG |
Protein Description |
Partial |
Tag Info |
Tag-Free |
Mol. Weight |
19.8 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine C3H10T1/2 cells is 0.5 - 1.0 ug/ml. |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered 20 mM PB, pH 7.4, 150mM NaCl , lyophilized |
Alias |
SHH, , ; Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product, ], |
Relevance |
Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}. |
PubMed ID |
7916661; 7720571; 16141072; 15489334; 7891723; 7736596; 8824192; 11486055; 14687547; 15075292; 16282375; 18081866; 7477329; 18794898; 19561611; 20519495 |
Function |
Sonic hedgehog protein |
Subcellular Location |
Sonic hedgehog protein N-product: Cell membrane, Lipid-anchor |
Protein Families |
Hedgehog family |
Tissue Specificity |
Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina. |
Tag Information |
Tag-Free |
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