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Recombinant Human DNA polymerase subunit gamma-2, mitochondrial(POLG2)

Recombinant Human DNA polymerase subunit gamma-2, mitochondrial(POLG2)

ArtNr	CSB-EP883399HU-50
Hersteller	Cusabio
Menge	50ug
Quantity options	1mg 10ug 100ug 20ug 200ug 50ug 500ug
Kategorie	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	E.coli
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DNA polymerase gamma accessory 55KDA subunit ;p55Mitochondrial DNA polymerase accessory subunitMtPolBPolG-beta
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Research Topic	Transcription
Uniprot ID	Q9UHN1
Gene Names	POLG2
Organism	Homo sapiens (Human)
AA Sequence	MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTE RSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALL EICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVE LRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLP GDSAFRLVSAETLREILQDKELSKEQLVAFLENVL KTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQ IGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPP RTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQD EEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMY PGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYL YDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVAL DVGRGPTLELRQVCQGLFNELLENGISVWPGYLET MQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHL RSRDTTMKEMMHISKLKDFLIKYISSAKNV
Expression Region	1-485aa
Sequence Info	Full Length
Source	E.coli
Tag Info	N-terminal 6xHis-SUMO-tagged
MW	70.9 kDa
Alternative Name(s)	DNA polymerase gamma accessory 55KDA subunit ; p55Mitochondrial DNA polymerase accessory subunitMtPolBPolG-beta
Relevance	Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
Reference	Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.Ferraris S., Clark S., Garelli E., Davidzon G., Moore S.A., Kardon R.H., Bienstock R.J., Longley M.J., Mancuso M., Gutierrez Rios P., Hirano M., Copeland W.C., DiMauro S.Arch. Neurol. 65:125-131(2008)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
Involvement in disease	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4 (PEOA4)
Subcellular Location	Mitochondrion
Tag Information	N-terminal 6xHis-SUMO-tagged

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