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Recombinant Human Plastin-2(LCP1)

ArtNr CSB-EP012824HU-500
Hersteller Cusabio
Menge 500ug
Kategorie
Typ Proteins Recombinant
Format Liquid or Lyophilized powder
Specific against other
Host E.coli
Purity Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias L-plastin;LC64PLymphocyte cytosolic protein 1 ;LCP-1
Lieferbar
Research areas
Cancer
Target / Protein
LCP1
Biologically active
Not Test
Expression system
E.coli
Species of origin
Homo sapiens (Human)
Uniprot ID
P13796
AA Sequence
ARGSVSDEEMMELREAFAKVDTDGNGYISFNELND LFKAACLPLPGYRVREITENLMATGDLDQDGRISF DEFIKIFHGLKSTDVAKTFRKAINKKEGICAIGGT SEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCR HVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTID ERTINKKKLTPFTIQENLNLALNSASAIGCHVVNI GAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNE ALIALLREGESLEDLMKLSPEELLLRWANYHLENA GCNKIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVP AVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVT ATDVVRGNPKLNLAFIANLFNRYPALHKPENQDID WGALEGETREERTFRNWMNSLGVNPRVNHLYSDLS DALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKK LENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLT LALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVN ETLREAKKSSSISSFKDPKISTSLPVLDLIDAIQP GSINYDLLKTENLNDDEKLNNAKYAISMARKIGAR VYALPEDLVEVNPKMVMTVFACLMGKGMKRV
Tag Info
N-terminal 6xHis-SUMO-tagged
Expression Region
2-627aa
Protein length
Full Length of Mature Protein
MW
86.2 kDa
Alternative Name(s)
L-plastin; LC64PLymphocyte cytosolic protein 1 ; LCP-1
Relevance
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
References
The DNA sequence and analysis of human chromosome 13.Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.Nature 428:522-528(2004)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Actin-binding protein
Involvement in disease
Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3; 13)(q27; q14), with BCL6.
Subcellular Location
Cytoplasm, cytoskeleton, Cell junction, Cell projection, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side
Tissue Specificity
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Tag Information
N-terminal 6xHis-SUMO-tagged

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500ug
Lieferbar: In stock
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