Recombinant Human Fibronectin(FN1),partial (Active)

Other Recombinant Protein

Cancer

FN1

1270-1546aa & 1721-2016aa

Dimer

62.7 kDa

Greater than 95% as determined by SDS-PAGE.

Lyophilized from a 0.2 um Filtered 12.5 mM Sodium Citrate, 1.25% Sucrose, pH 6.2

Fibronectin1(FN1) is a secreted protein and contains 12 fibronectin type-I domains, fibronectin type-II domains and 16 fibronectin type-III domains.Recombinant human fibronectin fragment, is a protein of ca.63 kDa containing a central cell-binding domain, a high affinity heparin-binding domain II, and CS1 site within the alternatively spliced III CS region of human fibronectin. Cells bind to a VLA-4 ligand, a CS-I site, and a VLA-5 ligand, a cell attachment domain, and virus vectors binds to a heparin binding domain II, which co-locates the cell and the virus vector on NovoNectin. This process enhances the density of both cells and vectors, and facilitates the gene transduction in the result.

Glomerulopathy with fibronectin deposits 2 (GFND2)

Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.

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