ArtNr |
CSB-AP005741HU-10 |
Hersteller |
Cusabio
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Human |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Classification |
Other Recombinant Protein |
Subdivision |
Others |
Research Areas |
Cardiovascular |
Uniprot NO. |
Q8NBP7 |
Gene Names |
PCSK9 |
Source |
Mammalian cell |
Expression Region |
31-152aa & 153-692aa |
Sequence |
QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFH RCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQA QAARRGYLTKILHVFHGLLPGFLVKMSGDLLELAL KLPHVDYIEEDSSVFAQ & SIPWNL ERITPPRY RADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVM VTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSG RDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFI RKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLAR AGVVLVTAAGNFRDDACLYSPASAPEVITVGATNA QDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCS TCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAEL RQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPP STHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDE ELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFG GEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVH CHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPN QCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQ VTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVV RSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQEL |
Protein Description |
Full Length |
Tag Info |
C-terminal Avi-tagged |
Mol. Weight |
14 & 59 kDa |
Biological Activity |
The ED50 as determined by its ability to bind Human LDLR in functional ELISA is less than 200 ug/ml |
Purity |
Greater than 95% as determined by SDS-PAGE. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um Filtered 50 mM HEPES, 150 mM NaCl, 20% Glycerol, pH 7.4 |
Alias |
Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1 |
Relevance |
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development. |
Function |
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members |
Involvement in disease |
Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) |
Subcellular Location |
Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus |
Protein Families |
Peptidase S8 family |
Tissue Specificity |
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. |
Paythway |
Cholesterolmetabolism |
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