Recombinant Human Interleukin-31(IL31) (Active)

Cytokine

Immunology

IL31

24-164aa

Full Length of Mature Protein

15.8 kDa

Greater than 95% as determined by SDS-PAGE.

Lyophilized from a 0.2 um filtered 20 mM PB, 150 mM NaCl, pH 7.4

Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rbeta). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNgamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.

Secreted

Tag-Free