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Recombinant Human Neurotrophin-3(NTF3) (Active)

Recombinant Human Neurotrophin-3(NTF3) (Active)

ArtNr	CSB-AP003801HU-1
Hersteller	Cusabio
Menge	1mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	Greater than 95% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Classification	Cytokine
Subdivision	Growth Factor
Research Areas	Neuroscience
Uniprot NO.	P20783
Gene Names	NTF3
Source	E.coli
Expression Region	139-257aa
Sequence	YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQV TVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGI DDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRID TSCVCALSRKIGRT
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	13.6 kDa
Biological Activity	The ED50 as determined by its ability to bind Human NTRK2 in functional ELISA is less than 10 ug/ml.
Purity	Greater than 95% as determined by SDS-PAGE.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	Lyophilized from a 0.2 um filtered 20 mM PB, 250 mM NaCl, pH 7.2
Alias	Neurotrophin-3; NT-3; HDNF; Nerve Growth Factor 2; NGF-2; Neurotrophic Factor; NTF3
Relevance	Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to beta-NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems.
Function	Seems to promote the survival of visceral and proprioceptive sensory neurons.
Subcellular Location	Secreted
Protein Families	NGF-beta family
Tissue Specificity	Brain and peripheral tissues.
Paythway	MAPKsignalingpathway
Tag Information	Tag-Free

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