« Zurück
Home /
Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein(TNFRSF11B) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein(TNFRSF11B) (Active)

ArtNr	CSB-AP003001HU-500
Hersteller	Cusabio
Menge	500ug
Quantity options	1mg 10ug 100ug 250ug 50ug 500ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	>95% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Lieferbar
Classification	Cytokine
Subdivision	Tumor Necrosis Factor
Research Areas	Immunology
Uniprot NO.	O00300
Uniprot Entry Name	TR11B_HUMAN
Gene Names	TNFRSF11B, OCIF, OPG
Source	E.Coli
Expression Region	22-194aa
Sequence	ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QH CTAKWKTV CAPCPDHYYT DSWHTSDECL YCSP VCKELQ YVKQECNRTH NRVCECKEGR YLEIEF CLKH RSCPPGFGVV QAGTPERNTV CKRCPDGF FS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK
Protein Description	Partial
Tag Info	Tag-Free
Mol. Weight	19.7 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of ? 1.0 x 105 IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 30 % acetonitrile, 0.1 % TFA , lyophilized
Alias	Osteoclastogenesis inhibitory factor,
Relevance	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269\|PubMed:22664871, ECO:0000269\|PubMed:9168977}.
PubMed ID	9108485; 9492069; 9688283; 14702039; 16421571; 15489334; 9571159; 15340161; 12110935; 9168977; 9603945; 9478964; 11505389; 22664871; 12189164
Function	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Involvement in disease	Paget disease of bone 5, juvenile-onset (PDB5)
Subcellular Location	Secreted
Tissue Specificity	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Paythway	Osteoclastdifferentiation
Tag Information	Tag-Free

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

CSB-AP003001HU-500-datasheet.pdf

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 500ug

lieferbar

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail

Angebot anfordern

Lieferzeit anfragen