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Recombinant Human Pleiotrophin protein(PTN) (Active)

Recombinant Human Pleiotrophin protein(PTN) (Active)

ArtNr	CSB-AP002931HU-100
Hersteller	Cusabio
Menge	100ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	>96% as determined by SDSPAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Classification	Cytokine
Subdivision	Growth Factor
Research Areas	Immunology
Uniprot NO.	P21246
Uniprot Entry Name	PTN_HUMAN
Gene Names	PTN, HBNF1, NEGF1
Source	E.Coli
Expression Region	33-168aa
Sequence	GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GL GTREGTRT GAECKQTMKT QRCKIPCNWK KQFG AECKYQ FQAWGECDLN TALKTRTGSL KRALHN AECQ KTVTISKPCG KLTKPKPQAE SKKKKKEG KK QEKMLD
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	15.3 kDa
Biological Activity	Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been precoated with 100 ul/well of a solution of 510 ug/ml rHuPTN.
Purity	>96% as determined by SDSPAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 m filtered PBS, pH 7.4 , lyophilized
Alias	PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule
Relevance	Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269\|PubMed:11278720, ECO:0000269\|PubMed:1768439}.
PubMed ID	1701634; 2270483; 1768439; 1457401; 8484754; 9299545; 14702039; 12690205; 15489334; 2388713; 1733956; 8241100; 8484780; 11278720; 20873783
Function	Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells
Subcellular Location	Secreted
Protein Families	Pleiotrophin family
Tissue Specificity	Osteoblast and brain.
Tag Information	Tag-Free

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