ArtNr |
CSB-AP001811HU-250 |
Hersteller |
Cusabio
|
Menge |
250ug |
Quantity options |
1mg
10ug
100ug
2ug
250ug
500ug
|
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Classification |
Cytokine |
Subdivision |
Interleukin |
Research Areas |
Immunology |
Uniprot NO. |
P29459 |
Uniprot Entry Name |
IL12A_HUMAN |
Gene Names |
IL12A, NKSF1 |
Source |
Mammalian cell |
Expression Region |
23-219aa&23-328aa |
Sequence |
p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DI TKDKTSTV EACLPLELTK NESCLNSRET SFIT NGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEF KTMN AKLLMDPKRQ IFLDQNMLAV IDELMQAL NF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 Subunit: IW ELKKDVYV VELDWYPDAP GEMVVLTCDT PEED GITWTL DQSSEVLGSG KTLTIQVKEF GDAGQY TCHK GGEVLSHSLL LLHKKEDGIW STDILKDQ KE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG D NKEYEYSVE CQEDSACPAA EESLPIEVMV DAV HKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLK NSRQV EVSWEYPDTW STPHSYFSLT FCVQVQG KSK REKKDRVFTD KTSATVICRK NASISVRAQ D RYYSSSWSEW ASVPCS |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
75.0 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using PHA-activated human T lymphoblasts is less than 0.05 ng/ml, corresponding to a specific activity of ? 2.0 x 107 IU/mg. |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
IL-12A, CLMF p35, IL-12 subunit p35, NK cell stimulatory factor chain 1, NKSF1 |
Relevance |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
PubMed ID |
1673147; 1674604; 16641997; 2204066; 1374259; 16548883; 10899108 |
Function |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
Subcellular Location |
Secreted |
Protein Families |
IL-6 superfamily |
Paythway |
Jak-STATsignalingpathway |
Tag Information |
Tag-Free |
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