ArtNr |
CSB-AP000981HU-500 |
Hersteller |
Cusabio
|
Menge |
500ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Classification |
Cytokine |
Subdivision |
Chemokine |
Research Areas |
Immunology |
Uniprot NO. |
O15444 |
Uniprot Entry Name |
CCL25_HUMAN |
Gene Names |
CCL25, SCYA25, TECK |
Source |
E.Coli |
Expression Region |
24-150aa |
Sequence |
M+QGVFEDCCL AYHYPIGWAV LRRAWTYRIQ E VSGSCNLPA AIFYLPKRHR KVCGNPKSRE VQR AMKLLDA RNKVFAKLHH NTQTFQAGPH AVKKL SSGNS KLSSSKFSNP ISSSKRNVSL LISANSG |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
14.3 kDa |
Biological Activity |
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml. |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
Chemokine TECK, Thymus-expressed chemokine |
Relevance |
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
PubMed ID |
9285413; 14702039; 15057824; 15489334; 10229797; 23341447 |
Function |
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
Subcellular Location |
Secreted |
Protein Families |
Intercrine beta (chemokine CC) family |
Tissue Specificity |
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine. |
Paythway |
Chemokinesignalingpathway |
Tag Information |
Tag-Free |
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