ArtNr |
CSB-AP000011HU-250 |
Hersteller |
Cusabio
|
Menge |
250ug |
Quantity options |
1mg
10ug
100ug
20ug
250ug
50ug
500ug
|
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Classification |
Hormone |
Subdivision |
Hormone |
Research Areas |
Signal Transduction |
Uniprot NO. |
P01241 |
Uniprot Entry Name |
SOMA_HUMAN |
Gene Names |
GH1 |
Source |
E.Coli |
Expression Region |
27-127aa |
Sequence |
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FE EAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNR EETQQK SNLELLRISL LLIQSWLEPV QFLRSV FANS LVYGASDSNV YDLLKDLEEG IQTLMGRL ED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
22.0 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 lymphoma cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 1.0 x 107 IU/mg. |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
Growth hormone, GH-N, Growth hormone 1, Pituitary growth hormone, |
Relevance |
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
PubMed ID |
386281; 377496; 6269091; 7169009; 2744760; 18473352; 16625196; 10931946; 15489334; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 8364549; 14997482; 10393484; 16807684; 3447173; 1549776; 7984244; 8943276; 8552145; 9152628; 9276733; 10391209; 11502836; 12655557; 15001589; 15713716; 17519310 |
Function |
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
Involvement in disease |
Growth hormone deficiency, isolated, 1A (IGHD1A); Growth hormone deficiency, isolated, 1B (IGHD1B); Kowarski syndrome (KWKS); Growth hormone deficiency, isolated, 2 (IGHD2) |
Subcellular Location |
Secreted |
Protein Families |
Somatotropin/prolactin family |
Paythway |
Jak-STATsignalingpathway |
Tag Information |
Tag-Free |
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