ArtNr |
CSB-PA552215-50ul |
Hersteller |
Cusabio
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
IHC, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
ATP:D-hexose 6-phosphotransferase antibody; FGQTL3 antibody; GCK antibody; GK antibody; GLK antibody; Glucokinase antibody; Hexokinase D pancreatic isozyme antibody; Hexokinase type IV antibody; Hexokinase-4 antibody; Hexokinase-D antibody; HHF3 antibody; HK IV antibody; HK4 antibody; HKIV antibody; HXK4_HUMAN antibody; HXKP antibody; LGLK antibody; MODY2 antibody, glucokinase (hexokinase 4) |
Similar products |
glucokinase (hexokinase 4) |
Lieferbar |
|
Immunogen Species |
Human |
UniprotID |
P35557 |
Immunogen |
Fusion protein of human GCK |
Applications info |
ELISA, IHC, ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
IHC:1:100-1:300 |
Background |
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
Conjugate |
Non-conjugated |
Buffer |
-20C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
Antigen affinity purification |
General Research Areas |
Cancer, Metabolism, Signal transduction |
Initial Research Areas |
Signal Transduction |
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