SCN5A Antibody

Q14524

ELISA, WB, IHC, WB:1:500-1:3000, IHC:1:50-1:100

WB:1:500-1:3000

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

Sebastian K.G. Maier, Circulation, Mar 2004, 109: 1421 - 1427.
T.R. Cummins, Neurology, Jan 2003, 60: 224 - 229.
Christopher A. Ahern, Circ. Res., May 2005, 96: 991 - 998.
Jyoti Dhar Malhotra, Circulation, Mar 2001, 103: 1303 - 1310.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Neuroscience