ArtNr |
CSB-PA613392LA01HU-50ug |
Hersteller |
Cusabio
|
Menge |
50ug |
Quantity options |
100ug
20ug
50ug
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CDK2/Cyclin A associated protein p45 antibody; Cyclin A/CDK2 associated protein p45 antibody; Cyclin-A/CDK2-associated protein p45 antibody; F box protein Skp2 antibody; F box/LRR repeat protein 1 antibody; F-box protein Skp2 antibody; F-box/LRR-repeat protein 1 antibody; FBL 1 antibody; FBL1 antibody; FBXL 1 antibody; FBXL1 antibody; FLB 1 antibody; FLB1 antibody; MGC1366 antibody; p45 antibody; p45skp2 antibody; S phase kinase associated protein 2 (p45) antibody; S phase kinase associated protein 2 antibody; S-phase kinase-associated protein 2 antibody; S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody; SKP 2 antibody; Skp2 antibody; SKP2_HUMAN antibody, S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2), SKP2, FBXL1 |
Similar products |
SKP2, FBXL1, S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) |
Lieferbar |
|
Immunogen Species |
Human |
UniprotID |
Q13309 |
Immunogen |
Recombinant Human S-phase kinase-associated protein 2 protein (1-424AA) |
Applications info |
ELISA, WB, IHC, Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
WB:1:500-1:5000 |
Dilution ratio 3 |
IHC:1:20-1:200 |
Background |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. |
Conjugate |
Non-conjugated |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Cancer, Cardiovascular, Cell biology |
Initial Research Areas |
Cell Biology |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.