ASPSCR1 Antibody

Human

Peptide sequence around aa.303 ca.307(P-Q-Q-E-Q) derived from Human ASPSCR1.

ELISA:1:2000-1:10000

Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.

Ladanyi, M. et al. (2001) Oncogene 20, 48-57.
Bogan, J.S. et al. (2003) Nature 425, 727-33.
Yu, C. et al. (2007) J Biol Chem 282, 7710-22.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Signal Transduction