ArtNr |
CSB-PA17749A0Rb-50ug |
Hersteller |
Cusabio
|
Menge |
50ug |
Quantity options |
100ug
20ug
50ug
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
ARVD antibody; ARVD1 antibody; FLJ16571 antibody; LDS5 antibody; MGC105479 antibody; MGC118722 antibody; prepro-transforming growth factor beta-3 antibody; RNHF antibody; TGF beta 3 antibody; TGF beta3 antibody; TGF-beta-3 antibody; TGFB 3 antibody; Tgfb3 antibody; TGFB3_HUMAN antibody; transforming growth factor beta 3 antibody; Transforming growth factor beta-3 antibody, Transforming growth factor beta-3 (TGF-beta-3) [Cleaved into: Latency-associated peptide (LAP)], TGFB3 |
Similar products |
TGFB3, Transforming growth factor beta-3 (TGF-beta-3) [Cleaved into: Latency-associated peptide (LAP)] |
Lieferbar |
|
Immunogen Species |
Human |
UniprotID |
P10600 |
Immunogen |
Recombinant Human Transforming growth factor beta-3 proprotein protein (301-412AA) |
Applications info |
ELISA, IHC, Recommended dilution: IHC:1:50-1:500 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
IHC:1:50-1:500 |
Background |
Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). |
Conjugate |
Non-conjugated |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Cancer, Signal transduction, Stem cells |
Initial Research Areas |
Signal Transduction |
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