RNF212 Antibody

Q495C1

ELISA, WB, IHC, Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

WB:1:200-1:1000

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Antigen Affinity Purified

Epigenetics and Nuclear Signaling