E2F6 Antibody

Human

Recombinant Human Transcription factor E2F6 protein (1-281AA)

ELISA:1:2000-1:10000

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Antigen Affinity Purified

Epigenetics and Nuclear Signaling