Relevance |
COC19 reacts with CD19 (B4), a 90 kDa molecule, which is expressed on approximately 5-25% of human peripheral blood lymphocytes. CD19 antigen is present on human B lymphocytes at most stages of maturation, from the earliest Ig gene rearrangement in pro-B cells to mature cell, as well as malignant B cells, but is lost on maturation to plasma cells. CD19 antibody does not react with T lymphocytes, monocytes and granulocytes. CD19 is a critical signal transduction molecule that regulates B lymphocyte development, activation and differentiation. This clone is cross reactive with non-human primate.* CD19 is a key phenotyping marker of non-T cell leukemia. 1. , Nadler, LM et al. (1983) J. Immunol. 131:2442. Schlossman, SL et al., eds. (1995) , Leucocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, New York.3. , Tedder T. et al. , (1994) , Immunol Today. 15:437-442 |