Relevance |
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. |
References |
[1] "Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones."Boyd D., Vecoli C., Belcher D.M., Jain S.K., Drysdale J.W.J. Biol. Chem. 260:11755-11761(1985) [2] "Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications."Dorner M.H., Salfeld J., Will H., Leibold E.A., Vass J.K., Munro H.N. Proc. Natl. Acad. Sci. U.S.A. 82:3139-3143(1985) [3] "Cloning of the gene coding for human L apoferritin."Santoro C., Marone M., Ferrone M., Costanzo F., Colombo M., Minganti C., Cortese R., Silengo L.Nucleic Acids Res. 14:2863-2876(1986) |