Anti Neuroglycan C (CSPG5) mAb (Clone C1)

Antibodies

-20C

Neurocan is a nervous tissue-unique, secretory proteoglycan that carries predominantly chondroitin sulfate side chains. Its expression gradually decreases with nervous tissue development. In the immature brain, neurocan exists in a full-length form with a 240 kDa-core glycoprotein, whereas in the mature brain it exists as proteolytic fragments of the NH2-terminal half (neurocan-N) with a 130 kDa-core glycopeptide and the COOH-terminal half (neurocan-C) with a 150 kDa-core glycopeptide. Neurocan is implicated in neural network formation and is a susceptibility factor for bipolar disorder. It is upregulated in central nervous system lesion sites and is a major component of glial scars. This antibody effectively recognizes the COOH-terminal half of rat neurocan core glycoprotein as well as the full length neurocan core glycoprotein.
References:
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3) Watanabe, E. et al. (1995) Eur. J. Neurosci. 7:547-554.
4) Fukuda, T. et al. (1997) J. Comp. Neurol. 382:141-152.
5) Inatani, M. et al. (1999) Invest. Ophthalmol. Vis. Sci. 40:2350-2359.