Anti Parvalbumin Alpha pAb (Rabbit, Affinity Purified)

Research Area/Organs & Organ Systems/Muscle/Primary Antibodies; Research Area/Disease/Alzheimer's Disease/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Neurobiology/Neurodegeneration/Primary Antibodies; Research Area/Cell Biology/Cytoskeleton/Primary Antibodies; Research Area/Organs & Organ Systems/Visual System/Primary Antibodies; Research Area/Disease/Fish Allergy/Primary Antibodies; Research Area/Disease/Fetal Alcohol Syndrome/Primary Antibodies; Antibodies/Primary Antibodies/Organs & Organ Systems/Muscle; Antibodies/Primary Antibodies/Disease/Alzheimer's Disease; Antibodies/Primary Antibodies/Cell Biology/Signal Transduction; Antibodies/Primary Antibodies/Neurobiology/Neurodegeneration; Antibodies/Primary Antibodies/Cell Biology/Cytoskeleton; Antibodies/Abs For Paraffin Embedded Tissue/Disease/Fetal Alcohol Syndrome; Antibodies/Primary Antibodies/Disease/Fish Allergy; Antibodies/Primary Antibodies/Disease/Fetal Alcohol Syndrome; Antibodies/Abs For Paraffin Embedded Tissue/Disease/Alzheimer's Disease; Antibodies/Abs For Paraffin Embedded Tissue/Organs & Organ Systems/Visual System; Antibodies/Abs For Paraffin Embedded Tissue/Cell Biology/Cytoskeleton; Antibodies/Abs For Paraffin Embedded Tissue/Cell Biology/Signal Transduction; Antibodies/Abs For Paraffin Embedded Tissue/Disease/Fish Allergy; Antibodies/Abs For Paraffin Embedded Tissue/Neurobiology/Neurodegeneration; Antibodies/Abs For Paraffin Embedded Tissue/Organs & Organ Systems/Muscle; Antibodies/Primary Antibodies/Organs & Organ Systems/Visual System; Research Area/Cell Biology/Cytoskeleton/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Signal Transduction/Abs For Paraffin Embedded Tissue; Research Area/Disease/Alzheimer's Disease/Abs For Paraffin Embedded Tissue; Research Area/Disease/Fetal Alcohol Syndrome/Abs For Paraffin Embedded Tissue; Research Area/Disease/Fish Allergy/Abs For Paraffin Embedded Tissue; Research Area/Organs & Organ Systems/Visual System/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Neurodegeneration/Abs For Paraffin Embedded Tissue; Research Area/Organs & Organ Systems/Muscle/Abs For Paraffin Embedded Tissue

Purified parvalbumin from rat skeletalmuscle.

Background
Neurodegenerative diseases such as Alzheimer' s disease and Parkinson' s disease have been increasing rapidly and have become a serious social problem. In recent years, new causative genes have been discovered for amyotrophic lateral sclerosis (ALS) and other intractable neurological diseases opening new avenues for research on pathogenesis. It has been suggested that aggregation and accumulation of specific proteins cause neurotoxicity and the formation of lesions, but the onset and progression mechanisms are still unclear. Neuropathological diagnostic and experimental model biomarkers are needed for drug construction, drug discovery, and therapeutic development.
Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurons which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

Antigen/Source
Clonality	Polyclonal

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