Rat Anti-Rat Type II Collagen IgG1 Antibody Assay Kit, TMB

ELISA

Gel Packs

Rheumatoid arthritis / autoimmune arthritis models

The Collagen-Induced Arthritis (CIA) rat model uses injections of incomplete Freund's adjuvant (IFA) emulsified with heterologous type II collagen to induce autoimmune arthritis. The development of antibodies to the heterologous collagen used for immunization is an important factor in the development of the CIA model. Given the highly conserved sequence of type II collagen, the antibodies against the immunized collagen can cross-react to autologous type II collagen in the experimental animal. This kit allows for characterization of the immune response to autologous type II collagen in rats, after immunization with heterologous type II collagen.

Pre-coat