Traxoprodil

134234-12-1

C20H25NO3

DMSO : >= 150 mg/mL (458.13 mM)

Membrane Transporter/Ion Channel; Neuronal Signaling

Traxoprodil (CP101, 606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC₅₀ of 10 nM. IC50 & Target: IC50: 10 nM (Neuroprotection)^[1] In Vivo: Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED₅₀ less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice^[1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity^[2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures^[3].