HAEGTFTSD

926018-45-3

C40H57N11O17

10 mM in DMSO

GPCR/G Protein

HAEGTFTSD is the first N-terminal 1-9 residues of GLP-1 peptide. In Vitro: The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from intestinal L-cells, in response to the ingestion of food. GLP-1 exerts multiple actions by stimulating insulin secretion from pancreatic beta-cells, in a glucose dependent manner (insulinotropic action). GLP-1 lowers circulating plasma glucagon concentration, by inhibiting its secretion (production) from alpha-cells. GLP-1 also exhibits properties like stimulation of beta-cell growth, appetite suppression, delays gastric emptying and stimulation of insulin sensitivity^[1]. The peptide analogs of GLP-1 are useful as glucagon-like peptide 1 receptor agonists^[2].