Proxyphylline

603-00-9

C10H14N4O3

10 mM in DMSO

GPCR/G Protein

Proxyphylline is a methylxanthine derivative clinical used as cardiac stimulant, vasodilator and bronchodilator. In Vitro: Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect^[1]. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 ug/mL proxyphylline^[2] In Vivo: In a double-blind cross-over study, proxyphylline exhibits bronchodilatory effect^[3]. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations^[3].