Vergleich

Canthaxanthin

ArtNr CS-6879-10mg
Hersteller ChemScene
CAS-Nr. 514-78-3
Menge 10mg
Kategorie
Typ Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 514-78-3
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Alternative Names
E 161g; all-trans-Canthaxanthin
CAS
514-78-3
Purity
>98%
Formula
C40H52O2
MWt
564.84
Solubility
DMSO : 5 mg/mL (8.85 mM; Need ultrasonic and warming)
Clinical Information
No Development Reported
Pathway
Metabolic Enzyme/Protease; NF-kappaB; Immunology/Inflammation
Target
Reactive Oxygen Species; Reactive Oxygen Species; Reactive Oxygen Species
Biological Activity
Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties. In Vitro: Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)[1]. At concentrations of 0.1 to 1 x 1000 uM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation[2]. In Vivo: Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 ug/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 +/- 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls[3]. Canthaxanthin inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose[4]. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity[5].

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Menge: 10mg
Lieferbar: In stock
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