Ribocil

1381289-58-2

C19H22N6OS

DMSO : >= 24.8 mg/mL (64.84 mM)

Anti-infection

Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 uM. Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 ug/ml versus MIC >= 64 ug/ml), inhibition of riboflavin synthesis (IC50 = 0.13 uM versus IC50 > 26 uM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd >= 10, 000 nM).[1]