Bergenin

477-90-7

C14H16O9

DMSO : 103.3 mg/mL (314.68 mM; Need ultrasonic and warming)

Autophagy; Metabolic Enzyme/Protease; NF-kappaB; Immunology/Inflammation

Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 uM (antiplasmodial) [3] Target: In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2]. In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-alpha, IL-1beta, and IL-6, which were increased in LPS-induced mouse mastitis [1].