Proadifen (hydrochloride)

62-68-0

C23H32ClNO2

DMSO : >= 40 mg/mL (102.57 mM)

Metabolic Enzyme/Protease

Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19uM). IC50 value: 19uM Target: P450 Proadifen HCl has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 uM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.