Biological Activity |
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 uM and 0.91 uM, respectively. IC50 & Target: IC50: 1.7 uM (DNMT1)[1] Kd: 0.91 uM (DNMT1)[1] In Vitro: DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 uM and 0.91 uM, respectively. DC_517 (1.25, 2.5, 5, and 10 uM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 uM) also dose-dependently induces apoptotic cell death in HCT116 cells[1]. |