Lacidipine

103890-78-4

C26H33NO6

H2O : < 0.1 mg/mL (insoluble); DMSO : >= 50 mg/mL (109.76 mM)

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-kappaB; Immunology/Inflammation; Neuronal Signaling

Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium Channel Lacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3].