Tedizolid

856866-72-3

C17H15FN6O3

DMSO : 10 mg/mL (27.00 mM; Need ultrasonic)

Anti-infection

Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. In Vitro: Tedizolid (0.25 ug/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP^[1]. In Vivo: For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema^[1].