[Met5]-Enkephalin, amide (TFA)

5-Methionine-enkephalin amide (TFA)

C29H37F3N6O8S

H2O

GPCR/G Protein; Neuronal Signaling

[Met5]-Enkephalin, amide TFA is an agonist for delta opioid receptors as well as putative zeta (zeta) opioid receptors. IC50 & Target: delta and zeta opioid receptor^[1] In Vitro: [Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 uM significantly reduces the total number of glial cells in culture^[1]. [Met5]-Enkephalin, amide acts via delta-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC₅₀ value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine^[2].