N-(p-amylcinnamoyl) Anthranilic Acid

110683-10-8

C21H23NO3

H2O : < 0.1 mg/mL (insoluble); DMSO : >= 125 mg/mL (370.47 mM)

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A₂ (PLA₂) inhibitor and TRP channel blocker^[1][2]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia^[3]. IC50 & Target: PLA₂^[1][2].
TRP channel^[1][2]. Calcium-activated chloride channels^[3]. In Vitro: N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 uM) completely blocks ADPR-induced whole-cell currents and H₂O₂-induced Ca²⁺ signals (IC₅₀=1.7 uM) in HEK293cells transfected with human TRPM2^[1].
N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 uM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells^[1].
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA2₂ inhibition^[1].