D-erythro-Sphingosine

123-78-4

C18H37NO2

DMSO : 250 mg/mL (834.75 mM; Need ultrasonic)

TGF-beta/Smad; Epigenetics; Metabolic Enzyme/Protease

D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC₅₀ of 8 uM. D-erythro-Sphingosine inhibits protein kinase C (PKC). IC50 & Target: EC50: 8 uM (p32-kinase)^[1]
PKC^[2][3] In Vitro: A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 uM and a peak activity at 10-20 uM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines^[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro^[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells^[3].