Ubiquitin Isopeptidase Inhibitor I, G5

108477-18-5

C19H14N2O7S

DMSO : >= 31 mg/mL (74.81 mM)

Apoptosis

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC₅₀ values of 1.76 and 1.6 uM in E1A and E1A/C9DN cells, respectively. IC50 & Target: IC50: 1.76 uM (E1A cells), 1.6 uM (E1A/C9DN cells)^[1] In Vitro: G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC₅₀s of 1.76 and 1.6 uM in E1A and E1A/C9DN cells, respectively^[1].