ArtNr |
CS-CSI12329 |
Hersteller |
Cell Sciences
|
Menge |
10 ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Mouse (Murine, Mus musculus) |
Host |
E.coli |
Purity |
>98% by SDS-PAGE and HPLC analyses. Endotoxin level is <0.1 ng per ug of TPO. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
TPO, myeloproliferative leukemia virus oncogene ligand, Mpllg, TPO-1, TPO-2, TPO-3, TPO-4, OTTMUSP00000023070, OTTMUSP00000023071 |
Lieferbar |
|
Biological Activity |
The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg. |
Description |
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets, in vivo . TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and mouse TPO exhibits cross-species reactivity. Recombinant mouse TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein. |
Formulation |
Sterile filtered and lyophilized from 10 mM Tris, pH 8.0. |
Molecular Weight |
18.7 kDa |
Reconstitution |
Centrifuge vial prior to opening. The mouse TPO should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20C. |
Storage and Stability |
The lyophilized TPO should be stored desiccated below 0C. Reconstituted TPO should be stored in working aliquots at -20C. Avoid repeated freeze-thaw cycles. |
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