Native Mouse S100 Calcium Binding Protein A6

S100A6 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. There are at least 13 members in the S100 gene family, which are located as a cluster on chromosome 1q21. S100A6 may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of the S100A6 gene are implicated in melanoma. S100A6 also called Calcyclin has been purified by HPLC (see Kuznicki et al. (1989) Biochem. J. 263: 951-956

It is recommended to reconstitute the lyophilized Mouse S100A6 in sterile 18MU-cm water not less than 100ug/ml, which can then be further diluted to other aqueous solutions.