Native Human Myeloperoxidase Antigen

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, MPO is subsequently cleaved into a light and heavy chain. The mature MPO is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. MPO is a peroxidase enzyme and lysosomal protein stored in azurophilic granules of the neutrophils. Since Human MPO has a heme pigment, it causes the green color in secretions rich in neutrophils.

Store at -20C