Native Human RBP/Retinol Binding Protein

Stable for one year at 2-4C.

Native Human RBP/Retinol Binding Protein is responsible for binding and transporting retinol (vitaminA). Native Human RBP/Retinol Binding Protein has a binding site for one molecule of retinol andcirculates in the plasma together with prealbumin in the form of a protein complex in amolar ratio of 1:1. This binding to prealbumin prevents greater glomerular losses of thehuman retinol-binding protein. Only the retinol-free form of the retinol-binding protein, which has no affinity for prealbumin, undergoes glomerular filtration unhindered as aresult of its low molecular weight, human Retinol Binding Protein is re-absorbed by thetubular cells and catabolized there.This explains the elevated serum level of human Retinol Binding Protein in advancedchronic renal insufficiency. Since human Retinol Binding Protein and human prealbuminare synthesized in the liver, their serum concentrations are reduced in acute and chronichepatic diseases. Decreased concentrations of Human Retinol Binding Protein have alsobeen observed in cystic fibrosis.