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Recombinant Human Cytochrome P450 2D6

ArtNr CS-CRL308B
Hersteller Cell Sciences
Menge 20 ug
Kategorie
Typ Proteins
Applikationen WB
Specific against Human (Homo sapiens)
Host Insect
Purity Greater than 40% (SDS-PAGE).
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products CYP2DL1, polypeptide 6, cytochrome P450, flavoprotein-linked monooxygenase, xenobiotic monooxygenase, microsomal monooxygenase, CPD6, CYP2D, MGC120389, MGC120390, P450-DB1, P450C2D, P450DB1, cytochrome P450 2D6, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), -metabolizing)-like 1, debrisoquine 4-hydroxylase
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Manufacturer - Category
Biomolecules
Description
Cytochrome P450 2D6 is a member of a complex family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which perform detoxification reaction on xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically defined by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2, LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The International Autoimmune Hepatitis Group therefore has subdivided the AIH type 2 into two subgroups: 2a with HCV and 2b without HCV. AIH 2a patients are often over 40 and predominantly male. The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques. Recombinant Human Cytochrome P450 2D6, also called liver/kidney microsomal antigen 1 is produced in SF9 is a glycosylated, polypeptide chain having a MW of 55.801 kDa.
Formulation
Recombinant Human LKM 1 is supplied at a of 1 mg/ml in 16 mM sodium phosphate buffer pH 7.6, 400 mM sodium chloride, 0.08 mM Kl and 20% glycerol.

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Menge: 20 ug
Lieferbar: In stock
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