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Recombinant Human IL-31

Recombinant Human IL-31

ArtNr	CS-CRI201A
Hersteller	Cell Sciences
Menge	5 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Transcription Factors Targets for Rodent Neurosciences Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines By Organ Skin Cancer Hepatic Cancer
Typ	Proteins
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>97% by SDS-PAGE and HPLC analyses.
Sequence	SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	IL-31, interleukin-31
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Biological Activity	Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation of U-87 MG human glioblastoma/astrocytoma cells. 5 ng/mL of rHuI-L31 can effectively induce STAT3 activation.
Description	Human Interleukin-31 (IL-31) is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
Endotoxin Level	Less than 1EU/ug of rHuIL-31 as determined by LAL method.
Formulation	Lyophilized from a 0.2um filtered concentrated solution in PBS, pH7.4.
Molecular Weight	15.8 kDa
Reconstitution	Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability	Stable at 2-8C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-8C. For longer term, store in working aliquots below -20C. Avoid repeated freeze/thaw cycles.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CS-CRI201A-datasheet.pdf

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Menge: 5 ug

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