ArtNr |
CS-CRG504C |
Hersteller |
Cell Sciences
|
Menge |
1.0 mg |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Host |
E.coli |
Purity |
>97% by HPLC and SDS-PAGE |
Sequence |
ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
GROg, CINC-2b, GRO3, MIP-2b, MIP2B, SCYB3, GRO3 oncogene, MGSA gamma, melanoma growth stimulatory activity gamma |
Lieferbar |
|
Biological Activity |
Determined by its ability to chemoattract CXCR2 transfected 293 cells using a concentration range of 10.0-100.0 ng/mL. |
Description |
The three GRO cDNAs encode 107 amino acid precursor proteins from which the N-terminal 34 amino acid residues are cleaved to generate the mature GROs. There are no potential N-linked glycosylation sites in the amino acid sequences. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B. Recombinant Human GRO-gamma is a single non-glycosylated polypeptide chain containing 73 amino acids. |
Endotoxin Level |
Less than 1EU/ug of rHuGRO-gamma/CXCL3 as determined by LAL method. |
Formulation |
Lyophilized from a 0.2um filtered concentrated solution in 20 mM PB, pH 7.4 + 50mM NaCl. |
Molecular Weight |
7.9 kDa |
Reconstitution |
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions. |
Storage and Stability |
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles. |
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