Native Human Ceruloplasmin (Ferroxidase)

Human Ceruloplasmin (CP) is also known as ferroxidase or iron(II):oxygen oxidoreductase. CP is an enzyme synthesized in the liver containing 8 atoms of copper in its structure. Although CP is often considered a copper transport protein, this is not its primary function, just as human hemoglobin is not a carrier of iron, although it contains iron. The main carrier for copper in the plasma of humans is albumin. CP enzyme (ferroxidase) catalyzes the oxidation of ferrous iron (Fe2+) to ferric iron (Fe3+), therefore assisting in CP enzyme transport in the plasma in association with transferrin, which can only carry iron in the ferric state. Human Ceruloplasmin enzyme has been used in the diagnosis of Wilsons Disease (hepatolenticular degeneration) and for detection of Hodgkins Disease, infections, malignancy and trauma.

ca.134 kDa