Recombinant Human IGF1 (Leu24/Ala31) Receptor Grade

Human [Leu24] [Ala31] Insulin-like Growth Factor-I (IGF-I) is an analog of human IGF-I with a Leu substitution in place of Tyr at position 24 and an Ala for Tyr at position 31 of the human IGF-I sequence. Human [Leu24] [Ala31], IGF-I has greatly reduced binding to the Type 1 IGF receptor and to the insulin receptor compared to IGF-I, [Leu24] IGF-I and [Leu60] IGF-I. Human[Leu24] [Ala31] IGF-I has normal binding to acid-stripped human serum binding proteins. Consequently human [Leu24] [Ala31] IGF-I is an extremely useful analog of IGF-I for investigating IGF actions largely independent of binding to the Type 1 IGF receptor.