Rabbit Anti-Human GDNFR2 pAb

Antibodies

Rabbit Anti-Human GFR alpha-2 pAb. Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRa, Ret ligand 2 (RETL2) or TGFa-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Recombinant Human GFR alpha-2 peptide corresponding to amino acids near the center of human GFR alpha-2. The amino acid sequences of the immunogenic peptide are identical to those of mouse and rat.