ArtNr |
CS-CPB104 |
Hersteller |
Cell Sciences
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
BCLX, bcl-xS, BCL-XL/S, BCL2L, Bcl-X, DKFZp781P2092, bcl-xL, OTTHUMP00000030550, OTTHUMP00000030551, OTTHUMP00000030553 |
Lieferbar |
|
Cross-Reactivity |
Does not react with other BCL2 family members. |
Description |
Rabbit Anti-Multispecies BCL2L1 Affinity Purified polyclonal antibody. BCL2L1 is a 30 kDa anti-apoptotic protein belonging to the BCL2 family. BCL2L1 prevents apoptosis through two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. BCL2L1 can be cleaved by caspases upon apoptotic activation, which converts BCL2L1 from, an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of BCL2L1 forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway. |
Formulation |
Liquid in PBS, pH 7.2 + 30% glycerol + 0.5% BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only. |
Immunogen |
Synthetic peptide surrounding amino acid 56 of human BCL2L1 |
Purification |
Biospecific affinity chromatography |
Storage and Stability |
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles. |
Specificity |
Human, mouse, rat. Detects the 30 kDa BCL2L1 protein. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.