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MCH5, CAP4, FLICE, MACH, apoptosis-related cysteine protease, ALPS2B, FLJ17672, MGC78473, FADD-homologous ICE/CED-3-like protease, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, OTTHUMP00000163720, caspase 8, caspase 8, cysteine protease, Mch5 isoform alpha, OTTHUMP00000163718, OTTHUMP00000163719, procaspase-8 |
Description |
Mouse Anti-Human Active Caspase 8 Clone C502S Affinity Purified monoclonal antibody. Caspase 8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase 8 is synthesized as inactive pro-enzyme. Activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase 8 is able to cleave and activate downstream caspases, such as caspase 3, -6, -7 and a death agonist member of the BCL2/BCL-xL family, Bid, leading to apoptosis. |